Covid 19

• It's a respiratory illness that can spread from person to person.

• It's a viral disease caused by the SARS Cove two virus that is a global pandemic.

• Viruses enter our cells and takes over because it wants to replicate its genetic material and produce more viral particles.

• We need antibodies to kill the virus and we need to prevent the virus from entering our cells!

• R0 (R-Naught) - The number of cases an infected person will cause by transmission:
  • Measles: R0 of 12-114
  • Covid 19: R0 of-2.2
  • Sars: R0 of 2.7
• This virus has spike proteins that are used to bind to the membrane of the human cells that they infect.
• The binding is activated by furin.
• This virus has a specific structure that allows it to bind at these 10 times more tightly than the SARS-COV.
• The virus can live for 72 hours and can live in the air for 3 hours and on cardboard for 24 hours.
• No known human antibodies as of yet.
• We are all susceptible.
• Zoonotic Virus: Mutated from animals into humans so we haven’t seen this virus before.
• There is a possibility of a second wave when people start coming back into the population. Will we see what happens in China?

What is the timeline we are looking at?

We are now testing.

Dr. Chris thinks it may get worse before it gets better. 60-90 days.

What does flattening the curve mean?

The concept of flattening the curve is to stagger the number of new cases over a longer period so that people have access to care.

How does your body fight viral attack?
Covid-19- 10-100 times more damaging to the lungs because of a viral tropism than the typical SARS.
This virus because of the damage, creates a “cytokine storm” trying to kill the virus so its typically not the virus that kills people.
80% will have a positive outcome to the virus.
20% will have a negative response to the virus including more serious symptoms and sometimes even death.

What are the 20%- Comorbidities (make you more likely to have a negative outcome to COVID-19):
CVD. Smoking: High % of smokers in China and Italy
Diabetes
Obesity
Elderly
Chronic pulmonary disease
Chronic liver or kidney disease
Radiation therapy
Autoimmune conditions
Chronic neurological diseases

https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/index.html